Phosphoramidon Disodium Salt

Research use only, not for human use.

Phosphoramidon Disodium Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool.

Phosphoramidon disodium is a neutral endopeptidase (neprilysin) inhibitor. It blocks degradation of amyloid β peptides and endothelin converting enzyme (ECE).

Phosphoramidon (1-500 μM; 30 min) inhibits ET-converting enzyme (ECE) activity in a dose-dependent manner in solubilized rabbit lung membranes.

Phosphoramidon (0.25 mg/kg per min; i.v.) suppresses the hypertensive effect of big endothelin-1 in rats. Phosphoramidon (1-30 mg/kg; i.v.; once) blocks the pressor activity of porcine big endothelin-1-(1-39) in rats. Animal Model:Male Sprague-Dawley ratsDosage:0.25 mg/kg per min Administration:Intravenous injection Result:Markedly suppressed the hypertensive effect of big endothelin-1.

Phosphoramidon disodium

Others

Other Targets

metalloendopeptidase

Others-Field

——

164204-38-0

588.48

C23H34N3Na2O10P

>98% (HPLC)

H2O : ≥ 140 mg/mL; 238.31 mM

[Na][Na].CC(C)C[C@H](NP(O)(=O)O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O)C(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(O)=O

sodium (oxido(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)phosphoryl)-L-leucyl-L-tryptophanate

(-20℃)

With Ice Pack

≥ 2 years